Granted (in shares) Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Grants in Period Aggregate intrinsic value, options outstanding Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding, Intrinsic Value Other income (expense) Other Nonoperating Income (Expense) Options, Granted (in shares) Share-based Compensation Arrangement by Share-based Payment Award, Options, Grants in Period, Gross Amortization of debt discount Amortization of Debt Discount (Premium) Accounts payable and accrued expenses Increase (Decrease) in Accounts Payable and Accrued Liabilities Corporate debt securities Short Term Corporate Debt Securities [Member] Short-term debt securities issued by domestic or foreign corporate business, banks and other entities with a promise of repayment. Vested (in dollars per share) Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Vested in Period, Weighted Average Grant Date Fair Value Level 3 Fair Value, Inputs, Level 3 [Member] Contingent consideration, measurement input Contingent Consideration, Measurement Input Contingent Consideration, Measurement Input Probability weighted discounted cash flow Probability Weighted Discounted Cash Flow [Member] Represents information pertaining to valuation technique of probability weighted discounted cash flow. Leases Lessee, Leases [Policy Text Block] Gross unrealized loss, Cash balances and available-for-sale securities Cash, Cash Equivalents And Available-for-sale Debt Securities, Accumulated Gross Unrealized Loss, Before Tax Cash, Cash Equivalents And Available-for-sale Debt Securities, Accumulated Gross Unrealized Loss, Before Tax Exchange agreement, aggregate principal amount Debt Instrument, Convertible Debt, Exchange Agreement, Aggregate Principal Amount Debt Instrument, Convertible Debt, Exchange Agreement, Aggregate Principal Amount Proceeds of exercise of warrants Proceeds from Warrant Exercises Statistical Measurement [Domain] Statistical Measurement [Domain] Liabilities and Stockholders’ Equity Liabilities and Equity [Abstract] Share-based Compensation Arrangement by Share-based Payment Award [Line Items] Share-based Compensation Arrangement by Share-based Payment Award [Line Items] Deferred income taxes Deferred Income Tax Liabilities, Net Equity component of the convertible notes Adjustments to Additional Paid in Capital, Equity Component of Convertible Debt Current Fiscal Year End Date Current Fiscal Year End Date In-process research & development Intangible Assets, Net (Excluding Goodwill) Loss from operations Operating Income (Loss) Entity Address, Postal Zip Code Entity Address, Postal Zip Code Total current liabilities Liabilities, Current Prepaid expenses and other current assets Prepaid Expense and Other Assets, Current Non-vested units (in dollars per share) Non-vested units (in dollars per share) Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Nonvested, Weighted Average Grant Date Fair Value Variable Rate [Domain] Variable Rate [Domain] Variable Rate [Axis] Variable Rate [Axis] Commitments and contingencies Commitments and Contingencies Marketable securities with maturity date greater than 12 months Debt Securities, Available-for-sale, Noncurrent Assets Assets [Abstract] Accounting Policies [Abstract] Accounting Policies [Abstract] Convertible notes Convertible Notes Payable, Noncurrent Cash, Cash Equivalents, Marketable Securities and Restricted Cash Cash and Cash Equivalents, Restricted Cash and Cash Equivalents, Policy [Policy Text Block] Stock-based compensation Shares Issued, Value, Share-based Payment Arrangement, after Forfeiture Entity Shell Company Entity Shell Company Vested (in shares) Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Vested in Period Cover page. Cover [Abstract] Accounts payable Accounts Payable, Current Document Type Document Type Accumulated deficit Retained Earnings (Accumulated Deficit) Repayments of credit facility Repayments of Lines of Credit Operating lease right-of-use assets, less accumulated amortization of $6,219 and $5,342 at June 30, 2020 and December 31, 2019, respectively Operating Lease, Right-of-Use Asset Less: debt discount Debt Instrument, Unamortized Discount Loss on exchange of convertible notes Loss on exchange of convertible debt Gain (Loss) on Extinguishment of Debt Schedule of liability components of long term debt Convertible Debt [Table Text Block] Options outstanding (in shares) Options outstanding (in shares) Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding, Number Deferred reimbursements Deferred Credits and Other Liabilities, Noncurrent New Accounting Pronouncements or Change in Accounting Principle [Line Items] New Accounting Pronouncements or Change in Accounting Principle [Line Items] Total operating expenses Operating Expenses Document Quarterly Report Document Quarterly Report Options, Exercisable (in shares) Share-based Compensation Arrangement by Share-based Payment Award, Options, Exercisable, Number Corporate debt securities, Gross Unrealized Loss Debt Securities, Available-For-Sale, Accumulated Gross Unrealized Loss, Before Tax, Current Debt Securities, Available-For-Sale, Accumulated Gross Unrealized Loss, Before Tax, Current Common stock, par value (in dollars per share) Common Stock, Par or Stated Value Per Share Valuation Approach and Technique [Domain] Valuation Approach and Technique [Domain] Other comprehensive gain (loss): Other Comprehensive Income (Loss), Net of Tax, Portion Attributable to Parent [Abstract] Other non-current liabilities Other Liabilities, Noncurrent Payment of finance leases Finance Lease, Principal Payments Investments in marketable securities Marketable Securities, Current Work-in-process Inventory, Work in Process, Net of Reserves Effect of exchange rate changes on cash, cash equivalents, and restricted cash Effect of Exchange Rate on Cash, Cash Equivalents, Restricted Cash and Restricted Cash Equivalents Inventories Total inventories Inventory, Net Entity File Number Entity File Number Business Acquisition [Axis] Business Acquisition [Axis] Geographical [Domain] Geographical [Domain] Accumulated other comprehensive loss: Accumulated Other Comprehensive Income (Loss), Net of Tax [Abstract] Exchange agreement, accrued and unpaid interest Debt Instrument, Convertible Debt, Exchange Agreement, Accrued And Unpaid Interest Debt Instrument, Convertible Debt, Exchange Agreement, Accrued And Unpaid Interest Other non-current assets and liabilities Increase (Decrease) In Noncurrent Operating Liabilities The increase (decrease) during the reporting period in the aggregate amount of noncurrent liabilities that result from activities that generate operating income. Statement [Line Items] Statement [Line Items] Schedule of potential shares of common stock that were excluded from the computation as they were anti-dilutive using the treasury stock method Schedule of Antidilutive Securities Excluded from Computation of Earnings Per Share [Table Text Block] Term Debt Instrument, Term Document Fiscal Period Focus Document Fiscal Period Focus Contingent consideration payable Business Combination, Contingent Consideration, Liability, Noncurrent Measurement Input Type [Domain] Measurement Input Type [Domain] Statement [Table] Statement [Table] Statistical Measurement [Axis] Statistical Measurement [Axis] Convertible notes Convertible Debt Securities [Member] Credit Facility [Axis] Credit Facility [Axis] Net loss attributable to common stockholders per common share - basic and diluted (in dollars per share) Earnings Per Share, Basic and Diluted Consolidation Consolidation, Policy [Policy Text Block] Increase (Decrease) in Stockholders' Equity Increase (Decrease) in Stockholders' Equity [Roll Forward] Fair Value Hierarchy and NAV [Domain] Fair Value Hierarchy and NAV [Domain] Debt Debt Disclosure [Text Block] Restricted stock tax vesting APIC, Share-based Payment Arrangement, Restricted Stock Unit, Increase for Cost Recognition Weighted average remaining contractual life, options exercisable Share-based Compensation Arrangement by Share-based Payment Award, Options, Exercisable, Weighted Average Remaining Contractual Term Proceeds from issuance of common stock, net of issuance costs Proceeds from Issuance of Common Stock Selling, general, and administrative expense Selling, General and Administrative Expenses [Member] Sale and redemption of marketable securities Proceeds from Sale and Maturity of Debt Securities, Available-for-sale Schedule of reconciliation of the numerator and denominator used in computing basic and diluted net loss per common share Schedule of Earnings Per Share, Basic and Diluted [Table Text Block] Denominator: Weighted Average Number of Shares Outstanding, Diluted [Abstract] Balance, beginning of the period Balance, end of the period Fair Value, Measurement with Unobservable Inputs Reconciliation, Recurring Basis, Liability Value Contingent Consideration Type [Domain] Contingent Consideration Type [Domain] Amendment Flag Amendment Flag Net cash used in operating activities Net Cash Provided by (Used in) Operating Activities Commercial paper Commercial Paper, Not Included with Cash and Cash Equivalents [Member] Corporate debt securities, Fair Value Debt Securities, Available-for-sale, Current Financial Instruments [Domain] Financial Instruments [Domain] Capital expenditures unpaid at the end of period Capital Expenditures Incurred but Not yet Paid Geographical [Axis] Geographical [Axis] Local Phone Number Local Phone Number Convertible Senior Notes 2016, Due 2023 Convertible Senior Notes2016 Due2023 [Member] Pertaining to the 3.0% unsecured Convertible Senior Notes due 2023 (the "Convertible Notes). Cost, available-for-sale securities Debt Securities, Available-for-sale, Amortized Cost Total unrecognized compensation costs Share-based Payment Arrangement, Nonvested Award, Option, Cost Not yet Recognized, Amount Gross unrealized gain, available-for-sale securities Debt Securities, Available-for-sale, Accumulated Gross Unrealized Gain, before Tax Statement of Cash Flows [Abstract] Statement of Cash Flows [Abstract] Proceeds from termination of capped call confirmations Proceeds From Capped Call Confirmations, Exchange Of Convertible Debt Proceeds From Capped Call Confirmations, Exchange Of Convertible Debt Schedule of Non-Vested RSU Activity under the Plan Share-based Payment Arrangement, Restricted Stock and Restricted Stock Unit, Activity [Table Text Block] Tenant improvements paid through lease incentives Payments for Tenant Improvements Income Statement Location [Axis] Income Statement Location [Axis] Income Statement Location [Domain] Income Statement Location [Domain] Other Comprehensive Gain (Loss) Comprehensive Income [Member] Financing activities Net Cash Provided by (Used in) Financing Activities [Abstract] Selling, general, and administrative Selling, General and Administrative Expense Entity Current Reporting Status Entity Current Reporting Status Purchase of vested restricted stock units Payments For Repurchase Of Restricted Stock Units The cash outflow to reacquire restricted stock units during the period. Threshold trading days Debt Instruments, Convertible, Threshold Trading Days Threshold number of specified trading days that common stock price to conversion price of convertible debt instruments must exceed threshold percentage within a specified consecutive trading period to trigger conversion feature, in 'PnYnMnDTnHnMnS' format, for example, 'P1Y5M13D' represents the reported fact of one year, five months, and thirteen days. Other non-current assets Other Assets, Noncurrent Plan Name [Axis] Plan Name [Axis] Threshold percentage Debt Instrument, Convertible, Threshold Percentage of Stock Price Trigger Stock issued from equity financing Stock Issued During Period, Value, New Issues Fair Value, Cash balances Cash and Cash Equivalents, Fair Value Disclosure Restricted stock tax vesting (in shares) Stock Issued During Period, Shares, Restricted Stock Award, Net of Forfeitures Total Assets Assets Non-vested units (in shares) Non-vested units (in shares) Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Nonvested, Number Subsequent Event Type [Axis] Subsequent Event Type [Axis] Antidilutive Securities [Axis] Antidilutive Securities [Axis] Entity Small Business Entity Small Business Concentration of Credit Risk Concentration Risk, Credit Risk, Policy [Policy Text Block] Interest expense Interest Expense Depreciation and amortization Depreciation and amortization Depreciation, Depletion and Amortization Entity Filer Category Entity Filer Category Total liabilities Liabilities Entity Address, City or Town Entity Address, City or Town Unrecognized compensation costs, period for recognition (in years) Share-based Payment Arrangement, Nonvested Award, Cost Not yet Recognized, Period for Recognition Valuation Approach and Technique [Axis] Valuation Approach and Technique [Axis] Expected stock price volatility Share-based Compensation Arrangement by Share-based Payment Award, Fair Value Assumptions, Expected Volatility Rate Ex-U.S. Non-US [Member] Weighted average remaining contractual life, options vested and unvested expected to vest Share-based Compensation Arrangement by Share-based Payment Award, Options, Vested and Expected to Vest, Outstanding, Weighted Average Remaining Contractual Term Fair value of available-for-sale debt securities in unrealized loss positions Debt Securities, Available-for-sale, Unrealized Loss Position Corporate debt securities, Gross Unrealized Gain Debt Securities, Available-For-Sale, Accumulated Gross Unrealized Gain, Before Tax, Current Debt Securities, Available-For-Sale, Accumulated Gross Unrealized Gain, Before Tax, Current Inventories Increase (Decrease) in Inventories Less: deferred financing Deferred Offering Costs Fair Value, Recurring and Nonrecurring [Table] Fair Value, Recurring and Nonrecurring [Table] Document Fiscal Year Focus Document Fiscal Year Focus Gain (loss) on extinguishment of debt, fair value of common shares issued Gain (Loss) On Extinguishment Of Debt, Fair Value Of Common Shares Issued Gain (Loss) On Extinguishment Of Debt, Fair Value Of Common Shares Issued Number of Shares Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Nonvested, Number of Shares [Roll Forward] Raw materials Inventory, Raw Materials, Net of Reserves Debt Instrument [Axis] Debt Instrument [Axis] Additional Paid-In Capital Additional Paid-in Capital [Member] Termination of capped call confirmations Adjustments To Additional Paid In Capital Premiums Paid From Termination Of Capped Call Confirmations Amount of decrease in additional paid in capital (APIC) resulting from Termination of Capped Call Confirmations. Antidilutive Securities, Name [Domain] Antidilutive Securities, Name [Domain] Cash, Cash Equivalents, and Short-term Investments [Abstract] Cash, Cash Equivalents, and Short-term Investments [Abstract] Contingent Consideration by Type [Axis] Contingent Consideration by Type [Axis] Adjustments to reconcile net loss to net cash used in operating activities: Adjustments to Reconcile Net Income (Loss) to Cash Provided by (Used in) Operating Activities [Abstract] Unrealized gain (loss) on available-for-sale securities, net of tax impact of $122, $220, $66, and $220, respectively Unrealized holding gain (loss) on available-for-sale securities Other Comprehensive Income (Loss), Available-for-sale Securities Adjustment, Net of Tax, Portion Attributable to Parent Common stock, shares outstanding (in shares) Balance (in shares) Balance (in shares) Common Stock, Shares, Outstanding Fair value of the Convertible Notes Convertible Debt, Fair Value Disclosures Loss before income tax Income (Loss) from Continuing Operations before Income Taxes, Noncontrolling Interest Subsequent Event Subsequent Event [Member] Options outstanding (in dollars per share) Options outstanding (in dollars per share) Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding, Weighted Average Exercise Price Common stock, shares authorized (in shares) Common Stock, Shares Authorized Stock Option Plan Amended Restated 2007 Equity Incentive Plan Stock Option Plan Amended Restated2007 Equity Incentive Plan [Member] Pertaining to the Company's Amended and Restated 2007 Equity Incentive Plan. Proceeds from exercise of stock options Proceeds from Stock Options Exercised Foreign currency translation adjustment, tax expense (benefit) Other Comprehensive Income (Loss), Foreign Currency Translation Adjustment, Tax, Portion Attributable to Parent Document Period End Date Document Period End Date Contractual interest expense Interest Expense, Debt, Excluding Amortization Entity Registrant Name Entity Registrant Name Expected annual dividend per share (in dollars per share) Share Based Compensation Arrangement by Share Based Payment Award, Fair Value Assumptions Expected Dividend Per Share Represents the estimated dividend per share to be paid (expected dividends) to holders of the underlying shares over the option's term. Income Statement [Abstract] Income Statement [Abstract] Senior Loans Senior Loans [Member] Operating lease liabilities Operating Lease, Liability, Noncurrent Prepaid expenses and other current assets Increase (Decrease) in Prepaid Expense and Other Assets Schedule of cash, cash equivalents and marketable securities Cash, Cash Equivalents and Investments [Table Text Block] Use of Estimates Use of Estimates, Policy [Policy Text Block] Current assets: Assets, Current [Abstract] Interest income Investment Income, Interest Comprehensive loss Comprehensive Income (Loss), Net of Tax, Attributable to Parent Capital expenditures Payments to Acquire Property, Plant, and Equipment Cost, Cash balances and available-for-sale securities Cash, Cash Equivalents And Available-for-sale Debt Securities Cash includes currency on hand as well as demand deposits with banks or financial institutions. It also includes other kinds of accounts that have the general characteristics of demand deposits in that the customer may deposit additional funds at any time and effectively may withdraw funds at any time without prior notice or penalty. Cash equivalents, excluding items classified as marketable securities, include short-term, highly liquid Investments that are both readily convertible to known amounts of cash, and so near their maturity that they present minimal risk of changes in value because of changes in interest rates. Generally, only investments with original maturities of three months or less qualify under that definition. Also includes amount of investment in debt and equity securities categorized neither as held-to-maturity nor trading. Entity Tax Identification Number Entity Tax Identification Number Contingent consideration payable Business Combination, Contingent Consideration, Liability Proceeds from credit facility Proceeds from Secured Lines of Credit Net loss Net Income (Loss), Including Portion Attributable to Noncontrolling Interest Disaggregation of Revenue Disaggregation of Revenue [Table Text Block] Trading Symbol Trading Symbol Schedule of inventories for the period Schedule of Inventory, Current [Table Text Block] Long-term Debt, Type [Domain] Long-term Debt, Type [Domain] Stock-based compensation Share-based Payment Arrangement, Noncash Expense Foreign currency remeasurement loss Foreign Currency Remeasurement Gain (Loss), Before Tax Foreign Currency Remeasurement Gain (Loss), Before Tax Measurement Input Type [Axis] Measurement Input Type [Axis] Shares authorized for issuance (in shares) Debt Instrument, Convertible Debt, Exchange Agreement, Shares Authorized For Issuance Debt Instrument, Convertible Debt, Exchange Agreement, Shares Authorized For Issuance Net carrying value Long-term Debt Fair Value Disclosures [Abstract] Fair Value Disclosures [Abstract] Restricted cash Restricted Cash and Cash Equivalents City Area Code City Area Code Cost of goods sold Cost of Goods and Services Sold Available-for-sale debt securities Fair value, Available-for-sale debt securities Debt Securities, Available-for-sale Equity Components [Axis] Equity Components [Axis] Title of 12(b) Security Title of 12(b) Security Warrants exercised Stock Issued During Period, Value, Warrants Exercised This element represents Stock issued from exercise of warrants. Finished goods Inventory, Finished Goods, Net of Reserves Share-based Payment Arrangement [Abstract] Share-based Payment Arrangement [Abstract] Debt Instrument, Name [Domain] Debt Instrument, Name [Domain] Minimum Minimum [Member] Deferred reimbursements Increase (Decrease) In Deferred Reimbursements The increase (decrease) during the reporting period in the amount of deferred reimbursements. Operating lease liabilities Operating Lease, Liability, Current Adjustment for contingent consideration paid in stock Contingent Consideration Paid In Stock, Adjustment Contingent Consideration Paid In Stock, Adjustment Stock issued for contingent consideration Stock Issued During Period Value Contingent Consideration Stock Issued During Period Value Contingent Consideration Schedule of changes in contingent consideration payable Schedule of Business Acquisitions by Acquisition, Contingent Consideration [Table Text Block] Forfeited (in dollars per share) Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Forfeitures, Weighted Average Grant Date Fair Value Schedule of Fair Value of Options Schedule of Share-based Payment Award, Stock Options, Valuation Assumptions [Table Text Block] Asset-backed securities Asset-backed Securities [Member] U.S. UNITED STATES Options, Exercised (in dollars per share) Share-based Compensation Arrangements by Share-based Payment Award, Options, Exercises in Period, Weighted Average Exercise Price Schedule of cash, cash equivalents, and restricted cash Restrictions on Cash and Cash Equivalents [Table Text Block] Revenue: Revenues [Abstract] Assets and Liabilities Measured at Fair Value Fair Value Disclosures [Text Block] Operating activities Net Cash Provided by (Used in) Operating Activities [Abstract] Schedule of Stock Options Activity Share-based Payment Arrangement, Option, Activity [Table Text Block] Additional Disclosures Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Additional Disclosures [Abstract] ATB200 Pompe Program ATB200 Pompe Program [Member] Represents the information pertaining to ATB-200 Pompe program. Additional paid-in capital Additional Paid in Capital, Common Stock Subsequent Event Type [Domain] Subsequent Event Type [Domain] Foreign currency translation adjustment Accumulated Other Comprehensive Income (Loss), Foreign Currency Translation Adjustment, Net of Tax Statement of Stockholders' Equity [Abstract] Statement of Stockholders' Equity [Abstract] Assets: Assets, Fair Value Disclosure [Abstract] Amortization of deferred financing Amortization Deferred Financing Costs Amortization of specific incremental costs directly attributable to a proposed or actual offering of securities which are deferred at the end of the reporting period. Weighted Average Exercise  Price Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding, Weighted Average Exercise Price [Abstract] Non-cash changes in the fair value of contingent consideration payable Business Combination, Contingent Consideration Arrangements, Change in Amount of Contingent Consideration, Liability Research and development expense Research and Development Expense [Member] Gross unrealized gain, Cash balances and available-for-sale securities Cash, Cash Equivalents And Available-for-sale Debt Securities, Accumulated Gross Unrealized Gain, Before Tax Cash, Cash Equivalents And Available-for-sale Debt Securities, Accumulated Gross Unrealized Gain, Before Tax Accounts receivable Accounts Receivable, after Allowance for Credit Loss, Current Unrealized gain on available-for-sale securities AOCI, Debt Securities, Available-for-sale, Adjustment, after Tax Probability of achievement of milestones Measurement Input, Probability Of Milestone Achievement [Member] Measurement Input, Probability Of Milestone Achievement [Member] Gross unrealized loss, available-for-sale securities Debt Securities, Available-for-sale, Accumulated Gross Unrealized Loss, before Tax Foreign Currency Transactions Foreign Currency Transactions and Translations Policy [Policy Text Block] Weighted-average common shares outstanding - basic and diluted (in shares) Weighted Average Number of Shares Outstanding, Basic and Diluted Foreign currency translation adjustment (loss) gain, net of tax impact of $(2,090), $30, $(554), and $30, respectively Foreign currency translation adjustment Other Comprehensive Income (Loss), Foreign Currency Transaction and Translation Adjustment, Net of Tax, Portion Attributable to Parent Fair Value Measurement Inputs and Valuation Techniques [Table] Fair Value Measurement Inputs and Valuation Techniques [Table] Goodwill Goodwill Cash, Money Market Funds, and Marketable Securities Debt Securities, Available-for-sale [Line Items] Schedule of significant unobservable inputs used in the valuation of the contingent consideration payable Fair Value Measurement Inputs and Valuation Techniques [Table Text Block] Other comprehensive income Other Comprehensive Income (Loss), Net of Tax, Portion Attributable to Parent Clinical and regulatory milestones Contingent Consideration Liability Clinical And Regulatory Milestones [Member] Represents information pertaining to clinical and regulatory contingent consideration milestones. Collaborative Arrangement and Arrangement Other than Collaborative [Domain] Collaborative Arrangement and Arrangement Other than Collaborative [Domain] Warrants Outstanding warrants, convertible to common stock Warrant [Member] Numerator: Net Income (Loss) Attributable to Parent [Abstract] Realized gain (loss) on debt securities Debt Securities, Realized Gain (Loss) Other income (expense): Nonoperating Income (Expense) [Abstract] Level 2 Fair Value, Inputs, Level 2 [Member] Liabilities: Liabilities, Fair Value Disclosure [Abstract] Options, Forfeited (in shares) Share-based Compensation Arrangement by Share-based Payment Award, Options, Forfeitures in Period Fair value of assets Assets, Fair Value Disclosure Schedule of Antidilutive Securities Excluded from Computation of Earnings Per Share [Table] Schedule of Antidilutive Securities Excluded from Computation of Earnings Per Share [Table] Entity Central Index Key Entity Central Index Key Entity Emerging Growth Company Entity Emerging Growth Company Options, Granted (in dollars per share) Share-based Compensation Arrangements by Share-based Payment Award, Options, Grants in Period, Weighted Average Exercise Price Options, Vested and unvested expected to vest (in shares) Share-based Compensation Arrangement by Share-based Payment Award, Options, Vested and Expected to Vest, Outstanding, Number Credit Facility [Domain] Credit Facility [Domain] Summary of assets and liabilities subject to fair value measurements Fair Value Measurements, Recurring and Nonrecurring [Table Text Block] Expected life of options (years) Share-based Compensation Arrangement by Share-based Payment Award, Fair Value Assumptions, Expected Term Available-for-sale securities, tax expense (benefit) OCI, Debt Securities, Available-for-Sale, Gain (Loss), after Adjustment, Tax Forfeited (in shares) Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Forfeited in Period Options, Expired (in shares) Share-based Compensation Arrangement by Share-based Payment Award, Options, Expirations in Period Debt Disclosure [Abstract] Debt Disclosure [Abstract] Warrants exercised (in shares) Stock Issued During Period, Shares, Warrants Exercised This element represents Stock issued from exercise of warrants (in shares). Amortization of debt discount and deferred financing Amortization of Debt Issuance Costs and Discounts Net cash provided by financing activities Net Cash Provided by (Used in) Financing Activities Reserve for inventory Inventory Valuation Reserves Aggregate intrinsic value, exercisable Share-based Compensation Arrangement by Share-based Payment Award, Options, Vested and Expected to Vest, Exercisable, Aggregate Intrinsic Value Total equity compensation expense Share-based Payment Arrangement, Expense Cash, Cash Equivalents, Marketable Securities, and Restricted Cash Cash, Cash Equivalents, and Short-term Investments [Text Block] Net product sales Revenue from Contract with Customer, Including Assessed Tax Common stock, $0.01 par value, 500,000,000 shares authorized, 258,223,842 and 255,417,869 shares issued and outstanding at June 30, 2020 and December 31, 2019, respectively Common Stock, Value, Issued Senior secured term loan Secured Long-term Debt, Noncurrent Deferred compensation plan liability Deferred Compensation Share-based Arrangements, Liability, Current and Noncurrent Contingent consideration paid in shares Contingent Consideration Paid in Stock Contingent Consideration Paid in Stock Changes in fair value of contingent consideration payable Changes in fair value during the period, included in the Consolidated Statements of Operations Fair Value, Measurement with Unobservable Inputs Reconciliation, Recurring Basis, Liability, Gain (Loss) Included in Earnings Schedule of Debt Instruments Schedule of Long-term Debt Instruments [Table] Granted (in dollars per share) Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Grants in Period, Weighted Average Grant Date Fair Value Inventory Disclosure [Abstract] Inventory Disclosure [Abstract] Investing activities Net Cash Provided by (Used in) Investing Activities [Abstract] Common stock, shares issued (in shares) Common Stock, Shares, Issued Cash and cash equivalents Cash and cash equivalents Cash and Cash Equivalents, at Carrying Value Accumulated depreciation and amortization on finance and operating lease right-of-use leases Accumulated Depreciation And Amortization, Finance And Operating Right-Of-Use Leases Accumulated Depreciation And Amortization, Finance And Operating Right-Of-Use Leases Accounts receivable Increase (Decrease) in Accounts Receivable Debt Instrument [Line Items] Debt Instrument [Line Items] Statement of Comprehensive Income [Abstract] Statement of Comprehensive Income [Abstract] Total stockholders’ equity Balance Balance Stockholders' Equity Attributable to Parent Stock issued for contingent consideration (in shares) Stock Issued During Period Shares Contingent Consideration Stock Issued During Period Shares Contingent Consideration Total Liabilities and Stockholders’ Equity Liabilities and Equity Fair Value Hierarchy and NAV [Axis] Fair Value Hierarchy and NAV [Axis] Unvested restricted stock units Restricted Stock Units (RSUs) [Member] Financial Instrument [Axis] Financial Instrument [Axis] Antidilutive securities excluded from computation of diluted earnings per share (in shares) Antidilutive Securities Excluded from Computation of Earnings Per Share, Amount Options to purchase common stock Options to purchase common stock Employee And Directors Stock Options [Member] An arrangement whereby an employee or member of the Board of Directors is entitled to receive in the future, subject to vesting and other restrictions, a number of shares in the entity at a specified price, as defined in the agreement. Equity Component [Domain] Equity Component [Domain] Entity Address, Address Line One Entity Address, Address Line One Gross profit Gross Profit Property and equipment, less accumulated depreciation of $21,194 and $17,604 at June 30, 2020 and December 31, 2019, respectively Property, Plant and Equipment, Net Revenue Recognition Revenue from Contract with Customer [Policy Text Block] Share-Based Compensation Share-based Payment Arrangement [Text Block] Net loss attributable to common stockholders Net loss Net loss Net loss attributable to common stockholders Net Income (Loss) Attributable to Parent Entity Address, State or Province Entity Address, State or Province Changes in operating assets and liabilities: Increase (Decrease) in Operating Capital [Abstract] Inventories Inventory Disclosure [Text Block] London Interbank Offered Rate (LIBOR) London Interbank Offered Rate (LIBOR) [Member] Senior Secured Term Loan due 2023 Senior Secured Term Loan due 2023 [Member] Senior Secured Term Loan due 2023 Long-term Debt, Type [Axis] Long-term Debt, Type [Axis] Total current assets Assets, Current Operating expenses: Operating Expenses [Abstract] Earnings Per Share [Abstract] Earnings Per Share [Abstract] Antidilutive securities Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items] Stockholders’ equity: Stockholders' Equity Attributable to Parent [Abstract] Entity Interactive Data Current Entity Interactive Data Current Number of Shares Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding [Roll Forward] U.S. government agency bonds US Government Corporations and Agencies Securities [Member] Entity Common Stock, Shares Outstanding Entity Common Stock, Shares Outstanding Inventories and Cost of Goods Sold Inventory Costs for Contracts or Programs, Policy [Policy Text Block] Variable rate (in percent) Debt Instrument, Variable Rate Debt Instrument, Variable Rate Fair value, Cash balances and available-for-sale securities Cash, Cash Equivalents And Available-for-sale Debt Securities Fair Value Disclosure Represents the portion of the balance sheet assertion valued at fair value by the entity whether such amount is presented as a separate caption or as a parenthetical disclosure. Additionally, this element may be used in connection with the fair value disclosures required in the footnote disclosures to the financial statements. The element may be used in both the balance sheet and disclosure in the same submission. This item represents cash and cash equivalents and marketable securities. Certificates of deposit Certificates of Deposit [Member] Entity Incorporation, State or Country Code Entity Incorporation, State or Country Code Supplemental disclosures of cash flow information Supplemental Cash Flow Information [Abstract] Business Acquisition, Acquiree [Domain] Business Acquisition, Acquiree [Domain] Schedule of Equity Compensation Expenses Share-based Payment Arrangement, Expensed and Capitalized, Amount [Table Text Block] Common Stock Common Stock [Member] Convertible Notes Convertible Debt [Member] Secured Debt Secured Debt [Member] Stock issued from equity financing (in shares) Stock Issued During Period, Shares, New Issues Equity component of the convertible notes (in shares) Stock Issued During Period, Shares, Conversion of Convertible Securities Money market Money market funds Money Market Funds [Member] Accumulated depreciation of property and equipment Accumulated Depreciation, Depletion and Amortization, Property, Plant, and Equipment Aggregate intrinsic value, vested and unvested expected to vest Share-based Compensation Arrangement by Share-based Payment Award, Options, Vested and Expected to Vest, Outstanding, Aggregate Intrinsic Value Stock issued from exercise of stock options, net (in shares) Options, Exercised (in shares) Share-based Compensation Arrangement by Share-based Payment Award, Options, Exercises in Period Net increase in cash, cash equivalents, and restricted cash at the end of the period Cash, Cash Equivalents, Restricted Cash and Restricted Cash Equivalents, Period Increase (Decrease), Including Exchange Rate Effect Basis of Presentation Basis of Accounting, Policy [Policy Text Block] Corporate debt securities, Cost Debt Securities, Available-for-sale, Amortized Cost, Current Basis spread on variable rate (in percent) Debt Instrument, Basis Spread on Variable Rate Risk free interest rate Share-based Compensation Arrangement by Share-based Payment Award, Fair Value Assumptions, Risk Free Interest Rate Options, Forfeited (in dollars per share) Share-based Compensation Arrangements by Share-based Payment Award, Options, Forfeitures in Period, Weighted Average Exercise Price Plan Name [Domain] Plan Name [Domain] Cash paid during the period for interest Interest Paid, Excluding Capitalized Interest, Operating Activities Description of Business Organization, Consolidation and Presentation of Financial Statements Disclosure [Text Block] Income tax expense Income Tax Expense (Benefit) Cash, cash equivalents, and restricted cash at beginning of period Cash, cash equivalents, and restricted cash at the end of period Cash, cash equivalents, and restricted cash shown in the Consolidated Statements of Cash Flows Cash, Cash Equivalents, Restricted Cash and Restricted Cash Equivalents Debt Securities, Available-for-sale [Table] Debt Securities, Available-for-sale [Table] Purchases of marketable securities Payments to Acquire Marketable Securities New Accounting Pronouncements or Change in Accounting Principle [Table] Accounting Standards Update and Change in Accounting Principle [Table] Callidus Biopharma Inc Callidus Biopharma Inc [Member] Represents information pertaining to Callidus Biopharma, Inc. Fair value of liabilities Financial and Nonfinancial Liabilities, Fair Value Disclosure Gain (loss) on extinguishment of debt, additional paid-in capital Gain (Loss) On Extinguishment Of Debt, Additional Paid-In Capital Gain (Loss) On Extinguishment Of Debt, Additional Paid-In Capital Collaborative Arrangement and Arrangement Other than Collaborative [Axis] Collaborative Arrangement and Arrangement Other than Collaborative [Axis] Accrued expenses and other current liabilities Accrued Liabilities and Other Liabilities Fair Value, Liabilities Measured on Recurring Basis, Unobservable Input Reconciliation, Calculation [Roll Forward] Fair Value, Liabilities Measured on Recurring Basis, Unobservable Input Reconciliation, Calculation [Roll Forward] Long-term debt Long-term Debt, Gross Stock issued from exercise of stock options, net Stock Issued During Period, Value, Stock Options Exercised Threshold consecutive trading days Debt Instrument, Convertible, Threshold Consecutive Trading Days Credit facility maximum borrowing amount Line of Credit Facility, Maximum Borrowing Capacity Award Type [Axis] Award Type [Axis] Weighted Average Grant Date Fair Value Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Nonvested, Weighted Average Grant Date Fair Value [Abstract] Maximum Maximum [Member] Security Exchange Name Security Exchange Name Non-vested units, aggregate intrinsic value Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Aggregate Intrinsic Value, Nonvested Accumulated Deficit Retained Earnings [Member] Components of total interest expense Interest Income and Interest Expense Disclosure [Table Text Block] Financial assets and liabilities subject to fair value measurements Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] Summary of Significant Accounting Policies Significant Accounting Policies [Text Block] Net cash provided by investing activities Net Cash Provided by (Used in) Investing Activities Additional Disclosures Share-based Compensation Arrangement by Share-based Payment Award, Options, Additional Disclosures [Abstract] Weighted average remaining contractual life, options outstanding Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding, Weighted Average Remaining Contractual Term Schedule of Share-based Compensation Arrangements by Share-based Payment Award [Table] Schedule of Share-based Compensation Arrangements by Share-based Payment Award [Table] Allowance for doubtful accounts receivable Accounts Receivable, Allowance for Credit Loss Warrants Warrants and Rights Outstanding Award Type [Domain] Award Type [Domain] Document Transition Report Document Transition Report Corporate debt securities Corporate Debt Securities [Member] Options, Exercisable (in dollars per share) Share-based Compensation Arrangement by Share-based Payment Award, Options, Exercisable, Weighted Average Exercise Price 2020 Senior Term Loan 2020 Senior Term Loan [Member] 2020 Senior Term Loan Non-vested units, weighted average remaining years Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Outstanding, Weighted Average Remaining Contractual Terms Basic and Diluted Net Loss per Common Share Earnings Per Share [Text Block] Organization, Consolidation and Presentation of Financial Statements [Abstract] Organization, Consolidation and Presentation of Financial Statements [Abstract] Current liabilities: Liabilities, Current [Abstract] Research and development Research and Development Expense (Excluding Acquired in Process Cost) Fair Value Measurement Inputs and Valuation Techniques [Line Items] Fair Value Measurement Inputs and Valuation Techniques [Line Items] Options, Vested and unvested expected to vest (in dollars per share) Share-based Compensation Arrangement by Share-based Payment Award, Options, Vested and Expected to Vest, Outstanding, Weighted Average Exercise Price Options, Expired (in dollars per share) Share-based Compensation Arrangements by Share-based Payment Award, Options, Expirations in Period, Weighted Average Exercise Price Recent Accounting Developments New Accounting Pronouncements, Policy [Policy Text Block] Discount rate Measurement Input, Discount Rate [Member] Statement of Financial Position [Abstract] Statement of Financial Position [Abstract]