SEC Form 3

FORM 3

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 INITIAL STATEMENT OF BENEFICIAL OWNERSHIP OF SECURITIES Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934 or Section 30(h) of the Investment Company Act of 1940

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1. Name and Address of Reporting Person* Peist Kenneth (Last) (First) (Middle) 6 CEDAR BROOK DRIVE (Street) CRANBURY NJ 08512 (City) (State) (Zip)	2. Date of Event Requiring Statement (Month/Day/Year) 01/03/2011	3. Issuer Name and Ticker or Trading Symbol AMICUS THERAPEUTICS INC [ FOLD ]
		4. Relationship of Reporting Person(s) to Issuer (Check all applicable) Director 10% Owner X Officer (give title below) Other (specify below) VP, Intellectual Property	5. If Amendment, Date of Original Filed (Month/Day/Year)
			6. Individual or Joint/Group Filing (Check Applicable Line) X Form filed by One Reporting Person Form filed by More than One Reporting Person

Table I - Non-Derivative Securities Beneficially Owned
1. Title of Security (Instr. 4)	2. Amount of Securities Beneficially Owned (Instr. 4)	3. Ownership Form: Direct (D) or Indirect (I) (Instr. 5)	4. Nature of Indirect Beneficial Ownership (Instr. 5)
Common Stock	250	I	Shares held in custodial account for son

Table II - Derivative Securities Beneficially Owned (e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security (Instr. 4)	2. Date Exercisable and Expiration Date (Month/Day/Year)		3. Title and Amount of Securities Underlying Derivative Security (Instr. 4)		4. Conversion or Exercise Price of Derivative Security	5. Ownership Form: Direct (D) or Indirect (I) (Instr. 5)	6. Nature of Indirect Beneficial Ownership (Instr. 5)
	Date Exercisable	Expiration Date	Title	Amount or Number of Shares
Stock Options (right to buy)	(1)	12/10/2017	Common Stock	12,500	9.54	D
Stock Options (right to buy)	(2)	02/03/2019	Common Stock	11,000	10.36	D
Stock Options (right to buy)	(3)	11/16/2019	Common Stock	25,000	4.16	D
Stock Options (right to buy)	(4)	03/16/2020	Common Stock	10,000	3.32	D
Stock Options (right to buy)	(5)	06/15/2020	Common Stock	8,000	2.81	D

Explanation of Responses:

1. These options vest and become exercisable in a series of installments. The first installment, which consists of 25% of the total aggregate number of options granted, vested on December 10, 2008. The remaining options vest and become exercisable in a series of thirty-six equal installments, beginning on January 1, 2009.

2. These options vest and become exercisable in a series of installments. The first installment, which consists of 25% of the total aggregate number of options granted, vested on February 3, 2010. The remaining options vest and become exercisable in a series of thirty-six equal installments, beginning on March 1, 2010.

3. These options vest and become exercisable in a series of installments. The first installment, which consists of 25% of the total aggregate number of options granted, vested on November 16, 2010. The remaining options vest and become exercisable in a series of thirty-six equal installments, beginning on December 1, 2010.

4. These options vest and become exercisable in a series of installments. The first installment, which consists of 25% of the total aggregate number of options granted, will vest on March 16, 2011. The remaining options will vest and become exercisable in a series of thirty-six equal installments, beginning on April 1, 2011.

5. These options vest and become exercisable in a series of installments. The first installment, which consists of 25% of the total aggregate number of options granted, will vest on June 15, 2011. The remaining options will vest and become exercisable in a series of thirty-six equal installments, beginning on July 1, 2011.

Remarks:

	/s/ KENNETH PEIST	01/19/2011
	** Signature of Reporting Person	Date
Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
* If the form is filed by more than one reporting person, see Instruction 5 (b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
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