SEC Form 3

FORM 3

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 INITIAL STATEMENT OF BENEFICIAL OWNERSHIP OF SECURITIES Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934 or Section 30(h) of the Investment Company Act of 1940

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1. Name and Address of Reporting Person* Valenzano Ken (Last) (First) (Middle) 6 CEDAR BROOK DRIVE (Street) CRANBURY NJ 08512 (City) (State) (Zip)	2. Date of Event Requiring Statement (Month/Day/Year) 05/10/2010	3. Issuer Name and Ticker or Trading Symbol AMICUS THERAPEUTICS INC [ FOLD ]
		4. Relationship of Reporting Person(s) to Issuer (Check all applicable) Director 10% Owner X Officer (give title below) Other (specify below) VP, Pharmacology & Biology	5. If Amendment, Date of Original Filed (Month/Day/Year)
			6. Individual or Joint/Group Filing (Check Applicable Line) X Form filed by One Reporting Person Form filed by More than One Reporting Person

Table I - Non-Derivative Securities Beneficially Owned
1. Title of Security (Instr. 4)	2. Amount of Securities Beneficially Owned (Instr. 4)	3. Ownership Form: Direct (D) or Indirect (I) (Instr. 5)	4. Nature of Indirect Beneficial Ownership (Instr. 5)
Common Stock	1,708	D

Table II - Derivative Securities Beneficially Owned (e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security (Instr. 4)	2. Date Exercisable and Expiration Date (Month/Day/Year)		3. Title and Amount of Securities Underlying Derivative Security (Instr. 4)		4. Conversion or Exercise Price of Derivative Security	5. Ownership Form: Direct (D) or Indirect (I) (Instr. 5)	6. Nature of Indirect Beneficial Ownership (Instr. 5)
	Date Exercisable	Expiration Date	Title	Amount or Number of Shares
Stock Options (right to buy)	06/01/2009	06/09/2015	Common Stock	2,793	0.64	D
Stock Options (right to buy)	10/01/2009	10/20/2015	Common Stock	2,000	5.33	D
Stock Options (right to buy)	02/01/2010	02/28/2016	Common Stock	9,500	5.33	D
Stock Options (right to buy)	(1)	04/25/2017	Common Stock	13,334	13.43	D
Stock Options (right to buy)	(2)	02/05/2018	Common Stock	12,500	10.21	D
Stock Options (right to buy)	(3)	02/03/2019	Common Stock	12,000	10.36	D
Stock Options (right to buy)	(4)	11/16/2019	Common Stock	30,000	4.16	D

Explanation of Responses:

1. These options vest and become exercisable in a series of installments. The first installment, which consists of 25% of the total aggregate number of options granted, vested on April 25, 2008. The remaining options vest and become exercisable in a series of thirty-six equal monthly installments, beginning on May 1, 2008.

2. These options vest and become exercisable in a series of installments. The first installment, which consists of 25% of the total aggregate number of options granted, vested on February 5, 2009. The remaining options vest and become exercisable in a series of thirty-six equal monthly installments, beginning on March 1, 2009.

3. These options vest and become exercisable in a series of installments. The first installment, which consists of 25% of the total aggregate number of options granted, vested on February 3, 2010. The remaining options vest and become exercisable in a series of thirty-six equal monthly installments, beginning on March 1, 2010.

4. These options vest and become exercisable in a series of installments. The first installment, which consists of 25% of the total aggregate number of options granted, will vest on November 16, 2010. The remaining options will vest and become exercisable in a series of thirty-six equal monthly installments, beginning on December 1, 2010.

Remarks:

	/s/ KEN VALENZANO	05/19/2010
	** Signature of Reporting Person	Date
Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
* If the form is filed by more than one reporting person, see Instruction 5 (b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
Note: File three copies of this Form, one of which must be manually signed. If space is insufficient, see Instruction 6 for procedure.
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