SEC Form 4

FORM 4		UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934 or Section 30(h) of the Investment Company Act of 1940	OMB APPROVAL OMB Number: 3235-0287 Estimated average burden hours per response: 0.5
	Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).

1. Name and Address of Reporting Person* FHM IV LP (Last) (First) (Middle) 601 UNION STREET, SUITE 3200 (Street) SEATTLE WA 98101 (City) (State) (Zip)	2. Issuer Name and Ticker or Trading Symbol AMICUS THERAPEUTICS INC [ FOLD ]	5. Relationship of Reporting Person(s) to Issuer (Check all applicable) Director X 10% Owner Officer (give title below) Other (specify below)
	3. Date of Earliest Transaction (Month/Day/Year) 02/15/2008
	4. If Amendment, Date of Original Filed (Month/Day/Year)	6. Individual or Joint/Group Filing (Check Applicable Line) Form filed by One Reporting Person X Form filed by More than One Reporting Person

Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
1. Title of Security (Instr. 3)	2. Transaction Date (Month/Day/Year)	2A. Deemed Execution Date, if any (Month/Day/Year)	3. Transaction Code (Instr. 8)		4. Securities Acquired (A) or Disposed Of (D) (Instr. 3, 4 and 5)			5. Amount of Securities Beneficially Owned Following Reported Transaction(s) (Instr. 3 and 4)	6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4)	7. Nature of Indirect Beneficial Ownership (Instr. 4)
			Code	V	Amount	(A) or (D)	Price
Common Stock	02/20/2008		P		100	A	$9.5	646,267	I	By Frazier Healthcare V, LP(1)(2)
Common Stock	02/20/2008		P		200	A	$9.51	646,467	I	By Frazier Healthcare V, LP(1)(2)
Common Stock	02/20/2008		P		100	A	$9.53	646,567	I	By Frazier Healthcare V, LP(1)(2)
Common Stock	02/20/2008		P		200	A	$9.54	646,767	I	By Frazier Healthcare V, LP(1)(2)
Common Stock	02/20/2008		P		1,100	A	$9.55	647,867	I	By Frazier Healthcare V, LP(1)(2)
Common Stock	02/20/2008		P		200	A	$9.56	648,067	I	By Frazier Healthcare V, LP(1)(2)
Common Stock	02/20/2008		P		300	A	$9.57	648,367	I	By Frazier Healthcare V, LP(1)(2)
Common Stock	02/20/2008		P		300	A	$9.58	648,667	I	By Frazier Healthcare V, LP(1)(2)
Common Stock	02/20/2008		P		1,307	A	$9.59	649,974	I	By Frazier Healthcare V, LP(1)(2)
Common Stock	02/20/2008		P		9,309	A	$9.6	659,283	I	By Frazier Healthcare V, LP(1)(2)
Common Stock	02/20/2008		P		100	A	$9.61	659,383	I	By Frazier Healthcare V, LP(1)(2)
Common Stock	02/20/2008		P		28,481	A	$9.62	687,864	I	By Frazier Healthcare V, LP(1)(2)
Common Stock	02/20/2008		P		300	A	$9.63	688,164	I	By Frazier Healthcare V, LP(1)(2)
Common Stock	02/20/2008		P		400	A	$9.64	688,564	I	By Frazier Healthcare V, LP(1)(2)
Common Stock	02/20/2008		P		6,800	A	$9.65	695,364	I	By Frazier Healthcare V, LP(1)(2)
Common Stock	02/20/2008		P		100	A	$9.66	695,464	I	By Frazier Healthcare V, LP(1)(2)
Common Stock	02/20/2008		P		100	A	$9.67	695,564	I	By Frazier Healthcare V, LP(1)(2)
Common Stock	02/20/2008		P		100	A	$9.68	695,664	I	By Frazier Healthcare V, LP(1)(2)
Common Stock	02/20/2008		P		3	A	$9.82	695,667	I	By Frazier Healthcare V, LP(1)(2)
Common Stock								2,586,886	I	By Frazier Healthcare IV, LP(2)(3)
Common Stock								13,128	I	By Frazier Affiliates IV, LP(2)(3)

Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned (e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security (Instr. 3)	2. Conversion or Exercise Price of Derivative Security	3. Transaction Date (Month/Day/Year)	3A. Deemed Execution Date, if any (Month/Day/Year)	4. Transaction Code (Instr. 8)		5. Number of Derivative Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5)		6. Date Exercisable and Expiration Date (Month/Day/Year)		7. Title and Amount of Securities Underlying Derivative Security (Instr. 3 and 4)		8. Price of Derivative Security (Instr. 5)	9. Number of derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4)	10. Ownership Form: Direct (D) or Indirect (I) (Instr. 4)	11. Nature of Indirect Beneficial Ownership (Instr. 4)
				Code	V	(A)	(D)	Date Exercisable	Expiration Date	Title	Amount or Number of Shares

1. Name and Address of Reporting Person* FHM IV LP (Last) (First) (Middle) 601 UNION STREET, SUITE 3200 (Street) SEATTLE WA 98101 (City) (State) (Zip)

1. Name and Address of Reporting Person* Frazier Healthcare V, LP (Last) (First) (Middle) 601 UNION STREET, SUITE 3200 (Street) SEATTLE WA 98101 (City) (State) (Zip)

1. Name and Address of Reporting Person* FHM V, LP (Last) (First) (Middle) 601 UNION STREET, SUITE 3200 (Street) SEATTLE WA 98101 (City) (State) (Zip)

1. Name and Address of Reporting Person* FHM V, LLC (Last) (First) (Middle) 601 UNION STREET, SUITE 3200 (Street) SEATTLE WA 98101 (City) (State) (Zip)

1. Name and Address of Reporting Person* FRAZIER HEALTHCARE IV LP (Last) (First) (Middle) 601 UNION STREET, SUITE 3200 (Street) SEATTLE WA 98101 (City) (State) (Zip)

1. Name and Address of Reporting Person* FRAZIER AFFILIATES IV LP (Last) (First) (Middle) 601 UNION STREET, SUITE 3200 (Street) SEATTLE WA 98101 (City) (State) (Zip)

Explanation of Responses:

1. The securities are owned directly by Frazier Healthcare V, LP. FHM V, LP, a joint filer, serves as the general partner of Frazier Healthcare V, LP and FHM V, LLC, serves as the general partner of FHM V, LP. FHM V, LP and FHM V, LLC disclaim beneficial ownership of the reported securities except to the extent of their pecuniary interest therein.

2. There is no direct relationship among or between FHM V, LLC, FHM V, L.P. and Frazier Healthcare V, L.P., on the one hand, and FHM IV, LP, Frazier Healthcare IV, LP and Frazier Affiliates IV, LP, on the other. Beneficial ownership of Issuer shares as described herein and the inclusion of these shares in this report shall not be deemed an admission of beneficial ownership of the shares for purposes of Section 16 or for any other purpose.

3. The securities are owned directly by the entity listed. Frazier Healthcare IV, LP and Frazier Affiliates IV, LP are joint filers. The designated filer, FHM IV, LP, serves as the general partner of Frazier Healthcare IV, LP and Frazier Affiliates IV, LP. FHM IV, LP disclaims beneficial ownership of the reported securities, except to the extent of its proportionate pecuniary interest therein.

	FHM IV, LP, By: FHM IV, LLC, its General Partner, By: /s/ Thomas S. Hodge, Chief Operating Officer	02/20/2008
	Frazier Healthcare V, LP, By: FHM V, LP, its General Partner, By: FHM V, LLC, its General Partner, By: /s/ Thomas S. Hodge, Chief Operating Officer	02/20/2008
	FHM V, LP, By: FHM V, LLC, its General Partner, By: /s/ Thomas S. Hodge, Chief Operating Officer	02/20/2008
	FHM V, LLC, By: /s/ Thomas S. Hodge, Chief Operating Officer	02/20/2008
	Frazier Healthcare IV, LP, By: FHM IV, LP, its General Partner, By: FHM IV, LLC, its General Partner, By: /s/ Thomas S. Hodge, Chief Operating Officer	02/20/2008
	Frazier Affiliates IV, LP, By: FHM IV, LP, its General Partner, By: FHM IV, LLC, its General Partner, By: /s/ Thomas S. Hodge, Chief Operating Officer	02/20/2008
	** Signature of Reporting Person	Date
Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
* If the form is filed by more than one reporting person, see Instruction 4 (b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
Note: File three copies of this Form, one of which must be manually signed. If space is insufficient, see Instruction 6 for procedure.
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