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SEC FORM 4 SEC Form 4
FORM 4 UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934
or Section 30(h) of the Investment Company Act of 1940 		 
OMB APPROVAL
OMB Number: 3235-0287
Estimated average burden
hours per response: 0.5
Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).
1. Name and Address of Reporting Person*
Crowley John F
(Last) (First) (Middle)
C/O AMICUS THERAPEUTICS, INC.
6 CEDAR BROOK DRIVE
(Street)
CRANBURY NJ 08512
(City) (State) (Zip)
2. Issuer Name and Ticker or Trading Symbol
AMICUS THERAPEUTICS INC [ FOLD ] 		5. Relationship of Reporting Person(s) to Issuer
(Check all applicable)
X Director 10% Owner
X Officer (give title below) Other (specify below)
President and CEO
3. Date of Earliest Transaction (Month/Day/Year)
01/02/2008
4. If Amendment, Date of Original Filed (Month/Day/Year)
 6. Individual or Joint/Group Filing (Check Applicable Line)
X Form filed by One Reporting Person
Form filed by More than One Reporting Person
Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
1. Title of Security (Instr. 3) 2. Transaction Date (Month/Day/Year) 2A. Deemed Execution Date, if any (Month/Day/Year) 3. Transaction Code (Instr. 8) 4. Securities Acquired (A) or Disposed Of (D) (Instr. 3, 4 and 5) 5. Amount of Securities Beneficially Owned Following Reported Transaction(s) (Instr. 3 and 4) 6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4) 7. Nature of Indirect Beneficial Ownership (Instr. 4)
Code V Amount (A) or (D) Price
Common Stock 01/02/2008 M 20,000 A $0.638 68,736 D
Common Stock 01/02/2008 S(1) 100 D $10.13 73,233 I By John F. Crowley Grantor Retained Annuity Trust
Common Stock 01/02/2008 S(1) 100 D $10.14 73,133 I By John F. Crowley Grantor Retained Annuity Trust
Common Stock 01/02/2008 S(1) 400 D $10.18 72,733 I By John F. Crowley Grantor Retained Annuity Trust
Common Stock 01/02/2008 S(1) 1,400 D $10.21 71,333 I By John F. Crowley Grantor Retained Annuity Trust
Common Stock 01/02/2008 S(1) 900 D $10.25 70,433 I By John F. Crowley Grantor Retained Annuity Trust
Common Stock 01/02/2008 S(1) 600 D $10.26 69,833 I By John F. Crowley Grantor Retained Annuity Trust
Common Stock 01/02/2008 S(1) 99 D $10.28 69,734 I By John F. Crowley Grantor Retained Annuity Trust
Common Stock 01/02/2008 S(1) 1 D $10.29 69,733 I By John F. Crowley Grantor Retained Annuity Trust
Common Stock 01/02/2008 S(1) 100 D $10.32 69,633 I By John F. Crowley Grantor Retained Annuity Trust
Common Stock 01/02/2008 S(1) 100 D $10.33 69,533 I By John F. Crowley Grantor Retained Annuity Trust
Common Stock 01/02/2008 S(1) 399 D $10.34 69,134 I By John F. Crowley Grantor Retained Annuity Trust
Common Stock 01/02/2008 S(1) 400 D $10.35 68,734 D
Common Stock 01/02/2008 S(1) 201 D $10.36 68,533 I By John F. Crowley Grantor Retained Annuity Trust
Common Stock 01/02/2008 S(1) 200 D $10.67 68,333 I By John F. Crowley Grantor Retained Annuity Trust
Common Stock 01/02/2008 S(2) 100 D $10.15 59,900 I By Aileen A. Crowley 2007 Grantor Retired Annuity Trust
Common Stock 01/02/2008 S(2) 500 D $10.18 59,400(3) I By Aileen A. Crowley 2007 Grantor Retired Annuity Trust
Common Stock 01/02/2008 S(2) 81 D $10.2 59,319(3) I By Aileen A. Crowley 2007 Grantor Retired Annuity Trust
Common Stock 01/02/2008 S(2) 1,100 D $10.21 58,219(3) I By Aileen A. Crowley 2007 Grantor Retired Annuity Trust
Common Stock 01/02/2008 S(2) 900 D $10.25 57,319(3) I By Aileen A. Crowley 2007 Grantor Retired Annuity Trust
Common Stock 01/02/2008 S(2) 500 D $10.26 56,819(3) I By Aileen A. Crowley 2007 Grantor Retired Annuity Trust
Common Stock 01/02/2008 S(2) 219 D $10.27 56,600(3) I By Aileen A. Crowley 2007 Grantor Retired Annuity Trust
Common Stock 01/02/2008 S(2) 100 D $10.3 56,500(3) I By Aileen A. Crowley 2007 Grantor Retired Annuity Trust
Common Stock 01/02/2008 S(2) 100 D $10.31 56,400(3) I By Aileen A. Crowley 2007 Grantor Retired Annuity Trust
Common Stock 01/02/2008 S(2) 300 D $10.33 56,100(3) I By Aileen A. Crowley 2007 Grantor Retired Annuity Trust
Common Stock 01/02/2008 S(2) 200 D $10.34 55,900(3) I By Aileen A. Crowley 2007 Grantor Retired Annuity Trust
Common Stock 01/02/2008 S(2) 400 D $10.35 55,500(3) I By Aileen A. Crowley 2007 Grantor Retired Annuity Trust
Common Stock 01/02/2008 S(2) 200 D $10.36 55,300(3) I By Aileen A. Crowley 2007 Grantor Retired Annuity Trust
Common Stock 01/02/2008 S(2) 100 D $10.56 55,200(3) I By Aileen A. Crowley 2007 Grantor Retired Annuity Trust
Common Stock 01/02/2008 S(2) 200 D $10.67 55,000(3) I By Aileen A. Crowley 2007 Grantor Retired Annuity Trust
Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned
(e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security (Instr. 3) 2. Conversion or Exercise Price of Derivative Security 3. Transaction Date (Month/Day/Year) 3A. Deemed Execution Date, if any (Month/Day/Year) 4. Transaction Code (Instr. 8) 5. Number of Derivative Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5) 6. Date Exercisable and Expiration Date (Month/Day/Year) 7. Title and Amount of Securities Underlying Derivative Security (Instr. 3 and 4) 8. Price of Derivative Security (Instr. 5) 9. Number of derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4) 10. Ownership Form: Direct (D) or Indirect (I) (Instr. 4) 11. Nature of Indirect Beneficial Ownership (Instr. 4)
Code V (A) (D) Date Exercisable Expiration Date Title Amount or Number of Shares
Employee Stock Option (Right to Buy) $0.638 01/02/2008 M 20,000 (4) 01/06/2015 Common Stock 20,000 $0 89,930 D
Explanation of Responses:
1. Sales were made pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on August 13, 2007.
2. Sales were made pursuant to a Rule 10b5-1 trading plan adopted by the Aileen A. Crowley 2007 Grantor Retained Annuity Trust on August 13, 2007.
3. These shares are held by the Aileen A. Crowley 2007 Grantor Retained Annuity Trust. The reporting person disclaims beneficial ownership of the shares held by the Aileen A. Crowley 2007 Grantor Retained Annuity Trust, and the inclusion of these shares in this report shall not be deemed an admission of beneficial ownership of the shares for purposes of section 16 or for any other purpose.
4. These options vest and become exercisable in a series of installments. The first installment, which consisted of 25% of the total aggregate number of options granted, vested on January 3, 2006. The remaining options vest and become exercisable in a series of thirty-five successive equal monthly installments of 6,247 shares, beginning on February 3, 2006, with the final installment of 6,231 shares becoming exercisable on January 3, 2009.
/s/ John F. Crowley 01/04/2008
** Signature of Reporting Person Date
Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
* If the form is filed by more than one reporting person, see Instruction 4 (b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
Note: File three copies of this Form, one of which must be manually signed. If space is insufficient, see Instruction 6 for procedure.
Persons who respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB Number.